This inventor holds 6 USPTO granted patents. Top assignees: Agouron Pharmaceuticals, Inc., Eli Lilly and Company. Active years: 1995-2005.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 1995-2005
Title: Krzysztof Appelt: Innovator in Protein Engineering
Introduction
Krzysztof Appelt is a notable inventor based in Poway, California. He has made significant contributions to the field of protein engineering, particularly in the study of vascular endothelial growth factor receptor-2 (VEGFR2/KDR). With a total of 6 patents to his name, Appelt's work has implications for therapeutic advancements in various disease conditions.
Latest Patents
One of Appelt's latest patents involves modifications of the VEGF receptor-2 protein and methods of use. He has determined a 2.4 Å crystal structure of a protein construct containing the catalytic kinase domain of VEGFR2/KDR in an unliganded, phosphorylated state. This innovative protein construct features a modified catalytic linker and demonstrates comparable in vitro kinase activity to constructs containing the entire KID. The resulting construct retains similar in vitro kinase activity to that of the wild-type KID, allowing for complete crystallization of the protein, which can be characterized by X-ray crystallography. Furthermore, this invention discloses the use of X-ray crystallographic data for the identification and construction of potential therapeutic compounds aimed at treating various disease conditions.
Career Highlights
Throughout his career, Krzysztof Appelt has worked with prominent companies in the pharmaceutical industry, including Agouron Pharmaceuticals, Inc. and Eli Lilly and Company. His experience in these organizations has contributed to his expertise in protein engineering and therapeutic development.
Collaborations
Appelt has collaborated with several professionals in his field, including Chris Pinko and Anna M Tempcyzk-Russell. These collaborations have likely enriched his research and innovation efforts.
Conclusion
Krzysztof Appelt's contributions to protein engineering and his innovative patents highlight his role as a significant inventor in the field. His work continues to pave the way for advancements in therapeutic solutions for various diseases.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile