Kristine S Vogel

Title: The Innovative Contributions of Kristine S Vogel

Introduction

Kristine S Vogel is a prominent inventor based in Dallas, TX (US). She has made significant contributions to the field of pharmacology, particularly in understanding neurofibromin action. Her work has implications for both research and therapeutic applications in neurodegeneration.

Latest Patents

Kristine holds a patent for an "Assay for pharmacological agents that block neurofibromin action." This patent describes a targeted disruption of the NF1 gene in mice, demonstrating that both neural crest- and placode-derived sensory neurons from NF1(-/-) embryos can develop, extend neurites, and survive without neurotrophins. In contrast, their wild-type counterparts die rapidly unless NGF or BDNF is added to the culture medium. Furthermore, NF1 mutant sympathetic neurons can survive for extended periods and acquire mature morphology in the presence of NGF-blocking antibodies. This discovery is instrumental in screening candidate substances for inhibiting neurofibromin action and offers potential therapeutic avenues for neurodegeneration due to disease or trauma.

Career Highlights

Kristine is affiliated with the University of Texas System, where she continues her research and innovation. Her work has garnered attention for its potential to impact the understanding of neurodegenerative diseases.

Collaborations

One of her notable collaborators is Luis F Parada, with whom she has worked on various research projects related to neurobiology.

Conclusion

Kristine S Vogel's innovative work in pharmacology and her patent on neurofibromin action highlight her contributions to science and medicine. Her research not only advances our understanding of neurodegeneration but also opens new avenues for therapeutic interventions.