Company Filing History:
Years Active: 1993-2003
Title: Innovations of Krishnaswamy Krishnan
Introduction
Krishnaswamy Krishnan is an accomplished inventor based in Norwell, MA (US). He has made significant contributions to the field of medical diagnostics, particularly in the detection of cellular abnormalities associated with cancer. With a total of 4 patents, his work has the potential to impact the early detection and treatment of cervical cancer.
Latest Patents
One of his notable inventions is a method for the detection of cellular abnormalities using Fourier Transform Infrared Spectroscopy. This invention teaches a method to identify cellular abnormalities associated with disease states. The method utilizes infrared (IR) spectra of cell samples that are dried on an infrared-transparent matrix and scanned at a frequency range from 3000-950 cm. The identification of samples is based on establishing a reference using a representative set of spectra of normal and/or diseased specimens. During the reference assembly process, multivariate techniques such as Principal Component Analysis (PCA) and/or Partial Least Squares (PLS) are employed. PCA and PLS reduce the data based on maximum variations between the spectra and generate clusters in a multidimensional space representing different populations. The utilization of Mahalanobis distances or linear regression, such as Principle Component Regression on the reduced data from PCA, forms the basis for discrimination. This method is particularly effective in distinguishing premalignant and malignant stages of cervical cancer from normal cervical cells.
Another significant patent is a method for the detection of malignant and premalignant stages of cervical cancer. This invention discloses a method to identify these stages from an infrared (IR) spectrum of exfoliated cervical cells. Similar to his previous invention, this method also utilizes multivariate techniques for calibration and achieves statistically reliable distinctions between normal, dysplastic, and malignant samples.
Career Highlights
Throughout his career, Krishnaswamy Krishnan has worked with reputable companies such as Bio-Rad Laboratories, Inc. and Digilab, LLC. His expertise in the field of infrared spectroscopy and cellular analysis has positioned him as a valuable contributor to medical research and diagnostics.
Collaborations
Some of his notable coworkers include Menashi A Cohenford and Prashant S Bhandare. Their collaborative efforts have further advanced the research and development of innovative diagnostic methods.
Conclusion
Krishnaswamy Krishnan's