This inventor holds 1 USPTO granted patent. Top assignee: Aronex Pharmaceuticals, Inc.. Active years: 1997.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 1997
Title: Krishna Jayaraman: Innovator in Nucleic Acid Transport Technology
Introduction
Krishna Jayaraman is a notable inventor based in The Woodlands, TX (US). He has made significant contributions to the field of nucleic acid transport technology. His innovative work focuses on developing methods to deliver nucleic acids into cells effectively.
Latest Patents
Krishna holds a patent for an "Amphipathic nucleic acid transporter." This invention is designed to facilitate the delivery of nucleic acids into cells. The transporter comprises a cationic compound with a cationic head group that binds to the nucleic acid and a lipid tail that associates with the cell membrane. The cationic compound is typically a polyamine or a short basic peptide. The lipid tail can be selected from various compounds, including plant steroids, animal steroids, isoprenoid compounds, aliphatic lipids, pore-forming proteins, and fusogenic peptides. The cationic head and lipid tail are linked through a carbamate linkage. When using polyamines, spermidine or spermine is preferred. The nucleic acids can include triplex-forming oligonucleotides, antisense oligonucleotides, aptamers, ribozymes, plasmids, and DNA for gene therapy. Additionally, the patent describes a method for treating individuals using the transporter linked to a therapeutic nucleic acid.
Career Highlights
Krishna is currently employed at Aronex Pharmaceuticals, Inc., where he continues to advance his research in nucleic acid delivery systems. His work is pivotal in the development of new therapeutic approaches that leverage nucleic acids for medical treatments.
Collaborations
Throughout his career, Krishna has collaborated with talented individuals such as Nilabh Chaudhary and Veeraiah Bodepudi. These collaborations have enhanced the research and development efforts in his field.
Conclusion
Krishna Jayaraman's innovative contributions to nucleic acid transport technology highlight his role as a leading inventor in the field. His patent for the amphipathic nucleic acid transporter represents a significant advancement in therapeutic delivery systems.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile