Krishna J Fisher

Title: **Innovator Krishna J. Fisher: Pioneering Hybrid Virus Technologies**

Introduction

Krishna J. Fisher, based in New Orleans, LA, is a notable inventor recognized for his advancements in virology and gene therapy. With an impressive portfolio of 11 patents, Fisher's work focuses on hybrid virus vectors that enhance the delivery and integration of transgenes in host cells.

Latest Patents

Fisher's recent patents include innovative technologies such as the "Hybrid adenovirus-AAV virus and methods of use thereof." This invention presents a hybrid vector construct that incorporates adenoviral components alongside adeno-associated virus (AAV) ITR sequences. These hybrid vectors are designed to deliver high titer transgenes effectively into host cells, facilitating stable integration into the host's chromosomal DNA. Another significant patent, titled "Recombinant adenovirus and adeno-associated virus, cell lines and methods of production and use thereof," introduces an adenovirus E1/E4 expressing packaging cell line. This development allows for the generation of recombinant adenoviruses while enhancing the transduction efficiency of AAV by converting single-stranded recombinant viruses to their double-stranded forms.

Career Highlights

Fisher's work at the University of Pennsylvania has positioned him at the forefront of virology research. His innovative approaches in utilizing hybrid vectors are paving the way for advancements in gene therapy, offering potential solutions for various genetic disorders. His 11 patented inventions underscore a sustained commitment to improving viral vector technologies.

Collaborations

Throughout his career, Fisher has collaborated with esteemed colleagues, including James M. Wilson and William M. Kelley. These partnerships have fostered a collaborative environment that encourages the exchange of ideas and techniques essential for groundbreaking research in the field of gene therapy.

Conclusion

With a solid foundation in innovation and a proven track record, Krishna J. Fisher continues to contribute significantly to the field of virology. His patents reflect an ongoing commitment to enhancing gene delivery systems, which may one day transform therapeutic approaches for genetic diseases. As he collaborates with leading minds in the industry, Fisher's future endeavors promise to further advance our understanding and application of viral vector technologies.