Company Filing History:
Years Active: 2025
Title: Kohji Kusano: Innovator in Viral Vector Technology
Introduction
Kohji Kusano is a prominent inventor based in Tokyo, Japan. He has made significant contributions to the field of viral vector technology, holding 2 patents that focus on innovative approaches to gene therapy and regenerative medicine.
Latest Patents
Kusano's latest patents include a novel paramyxovirus vector. The objective of this invention is to provide an improved negative-strand RNA viral vector that exhibits transient high expression of genes loaded in the vector. This technology enables the rapid removal of the vector after expression. By adding a micro-RNA target sequence to the NP, P, or L gene of the viral vector, it is possible to control the expression based on the micro-RNA present in the introducing cell. Notably, when a micro-RNA target sequence is added to the NP or P gene, the expression of the vector decreases depending on the micro-RNA, promoting the vector's removal. Conversely, adding a micro-RNA target sequence to the L gene reverses this effect. This vector has potential applications in cell therapy and regenerative medicine, particularly as a therapeutic vector targeting cancer.
Another significant patent by Kusano involves polynucleotides for modifying target sequences. This invention provides donor polynucleotides formed by linking the ends of a genomic fragment containing a cleavable site with a polynucleotide carrying both a positive and a negative selection marker gene. The use of this donor polynucleotide allows for the modification of a target gene while minimizing the risk of introducing mutations to off-target sequences. This is achieved by introducing cleavage in a homologous site of the donor polynucleotide without affecting the target gene locus.
Career Highlights
Throughout his career, Kohji Kusano has worked with notable companies such as I'rom Group Co., Ltd. and Id Pharma Co., Ltd. His work has significantly advanced the understanding and application of viral vectors in therapeutic settings.
Collaborations
Kusano has collaborated with esteemed colleagues, including Makoto Inoue and Takayuki Kitogo. These partnerships have further enriched his research and innovations in the field.
Conclusion
Kohji Kusano is a distinguished inventor whose work in viral vector technology has the potential to revolutionize gene therapy and regenerative medicine. His innovative patents reflect a commitment to advancing medical science and