Klaus Totschnig

Title: Klaus Totschnig: Innovator in Pharmaceutical Chemistry

Introduction

Klaus Totschnig is a notable inventor based in Kundl, Austria. He has made significant contributions to the field of pharmaceutical chemistry, particularly in the development of novel compounds and processes. With a total of 4 patents to his name, Totschnig's work has had a meaningful impact on the industry.

Latest Patents

One of his latest patents involves a crystalline β-lactam intermediate. This novel intermediate compound, specifically 7-[2-(2-formylaminothiazol-4-yl)-2-(Z)-(methoxyimino)acetamido]-3-methoxymethyl-3-cephem-4-carboxylic acid-1-(isopropoxy), is crucial for the crystallization of cefpodoxime proxetil. The crystallization process he developed includes dissolving or suspending the intermediate in the presence of a nitrile or a ketone, at specific ratios, and isolating the intermediate in crystalline form. This innovative method allows for the conversion of the intermediate by splitting off the formyl group from the amino group attached to the thiazolyl group, resulting in the desired product in a diastereoisomeric mixture.

Career Highlights

Throughout his career, Klaus Totschnig has worked with prominent companies in the pharmaceutical sector, including Biochemie Gesellschaft M.b.h and Sandoz GmbH. His expertise in the field has led to advancements in the production of β-lactam compounds, which are essential in antibiotic development.

Collaborations

Totschnig has collaborated with notable colleagues such as Johannes Ludescher and Benjamin Gerlach. These partnerships have further enhanced his research and development efforts in pharmaceutical innovations.

Conclusion

Klaus Totschnig's contributions to pharmaceutical chemistry through his patents and collaborations highlight his role as an influential inventor in the industry. His innovative approaches continue to shape the future of drug development.