Kjeld Ove Olesen

Title: Kjeld Ove Olesen: Innovator in Customized Proteases

Introduction

Kjeld Ove Olesen is a notable inventor based in Frederiksberg, Denmark. He has made significant contributions to the field of biochemistry, particularly in the development of customized proteases. With a total of two patents to his name, Olesen's work has the potential to impact various applications in biotechnology and pharmaceuticals.

Latest Patents

Olesen's latest patents focus on customized proteases, which are mutant enzymes designed to enhance specific biochemical reactions. These inventions provide methods for creating customized proteases derived from known proteases. The altered transacylation reactions enable the performance of reactions that are not substantially catalyzed by the original proteases, or they improve yields in existing reactions. The methods involve site-specific or random mutagenesis of the active site amino acids of known proteases. Additionally, the customized proteases can be utilized to prepare preselected transacylation products, which can be modified by substituting nucleophiles such as L-amino acids, D-amino acids, amino acid amides, and radioactive amino acids.

Career Highlights

Olesen is currently associated with Carlsberg A/S, where he continues to innovate in the field of enzyme technology. His work has garnered attention for its potential applications in various industries, including food and beverage, pharmaceuticals, and biotechnology.

Collaborations

Olesen has collaborated with notable colleagues such as Klaus Breddam and Morten C Kielland-Brandt. These partnerships have contributed to the advancement of research and development in customized proteases.

Conclusion

Kjeld Ove Olesen's contributions to the field of customized proteases highlight his innovative spirit and dedication to advancing biochemistry. His patents reflect a commitment to enhancing enzymatic processes, which could lead to significant advancements in various applications.