Kiyoshi Sakai

Title: Kiyoshi Sakai and His Pharmaceutical Inventions.

Introduction

Kiyoshi Sakai is an inventor associated with Fujieda, Japan. His work includes inventions focused on improving the solubility and formulation of tissue plasminogen activator (t-PA), a physiologically active protein used in thrombolytic treatments. His listed portfolio includes 2 patents.

Latest Patents

Sakai’s patent, “Aqueous Solution of t-PA,” describes a method for dissolving proteins at high concentrations in aqueous solutions near their isoelectric point. The technique adds an anionic polymer or its salt to the solution and can be used to prepare pharmaceutical formulations containing physiologically active proteins.

His patent, “Method of Improving Solubility of Tissue Plasminogen Activator,” concerns thrombolytic compositions containing t-PA or a derivative, combined with an anionic polymer and an amine compound, with certain formulations also including an acid. The composition can be prepared as an aqueous solution or a lyophilized product that dissolves stably when diluted near neutral pH. The described approach is designed to work in both high-salt solutions, such as physiological saline, and low-salt solutions, such as 5% glucose solution, supporting products for infusion or injection.

Career Highlights

Sakai’s listed company affiliations include Mitsui Chemicals, Inc. and Mitsui Toatsu Chemicals, Incorporated. His patent work reflects a focus on practical pharmaceutical formulation challenges, particularly the stability and solubility of t-PA in solutions intended for clinical use.

Collaborations

His listed coworkers include Hisahiro Ishiwari and Yukio Shimazaki.

Conclusion

Kiyoshi Sakai’s inventions address the formulation of t-PA and other proteins, with an emphasis on stable solubility under conditions relevant to pharmaceutical preparations.