Kiyoshi Oguma

Title: Kiyoshi Oguma: Innovator in Peptide Chemistry

Introduction

Kiyoshi Oguma is a prominent inventor based in Saitama, Japan. He has made significant contributions to the field of peptide chemistry, holding a total of six patents. His work focuses on novel peptide derivatives and their applications in enzyme activity assays.

Latest Patents

One of his latest patents involves peptide derivatives that serve as substrates for the activity assay of enzymes such as cathepsin L, cathepsin B, and cathepsin H. These peptide derivatives, which include L-methionine radicals, are synthesized using conventional methods in peptide chemistry. Notable examples of these derivatives are D-leucyl-L-tyrosyl-L-methionine-.beta.-naphthylamide formate, .beta.-alanyl-L-tyrosyl-L-methionine-.beta.-naphthylamide formate, and succinyl-L-tyrosyl-L-methionine-p-nitroanilide. Another significant patent pertains to epoxysuccinyl amino acid derivatives, which exhibit inhibitory activity towards thiol proteases, particularly in muscle tissues affected by muscular dystrophy.

Career Highlights

Kiyoshi Oguma is currently associated with Taisho Pharmaceutical Co., Ltd., where he continues to innovate in the field of pharmaceuticals. His research has led to advancements that may improve therapeutic options for various conditions.

Collaborations

He has collaborated with notable colleagues such as Kazunori Hanada and Masaharu Tamai, contributing to a dynamic research environment that fosters innovation.

Conclusion

Kiyoshi Oguma's work in peptide chemistry exemplifies the impact of innovative research on medical science. His patents reflect a commitment to advancing our understanding of enzyme activity and therapeutic applications.