Company Filing History:
Years Active: 2009-2010
Title: **Kirsty Sarah Hewitson: Pioneering Innovations in Hydroxylase Modulation**
Introduction
Kirsty Sarah Hewitson, an accomplished inventor based in Oxford, GB, has made significant contributions to the field of biochemistry through her research and innovative patents. With a total of two patents to her name, Hewitson is recognized for her work in developing methods that have the potential to advance medical treatments related to oxygen sensing mechanisms in cells.
Latest Patents
One of her latest patents is titled "Method of identifying a chemical entity which is a hydroxylase modulator." This patent describes a method for identifying, screening, characterizing, or designing a chemical entity that can mimic or bind to the Factor Inhibiting HIF (FIH). The method utilizes a structural model of FIH that is derived from X-ray diffraction measurements of crystals comprising FIH. The applications of such chemical entities could be transformative in treating conditions related to fluctuating HIF levels or activity.
The second patent, "Assays for identifying modulators of the hydroxylation of ankyrin repeat proteins by 2-oxoglutarate dependent oxygenase," focuses on identifying agents that modulate the activity of 2-oxoglutarate dependent oxygenase. This involves creating a testing environment where the enzyme interacts with a substrate comprising ankyrin repeats, enabling the determination of hydroxylation in the presence or absence of the test agent.
Career Highlights
Hewitson's career has been marked by her innovative research that bridges the gap between chemistry and medical science. Her work has paved the way for potential therapeutic techniques targeting anemia, cancer, and other conditions influenced by oxygen levels in the body. She works at Isis Innovation Limited, a company known for fostering commercial opportunities arising from pioneering research.
Collaborations
Throughout her career, Kirsty has collaborated extensively with notable scientists such as Peter John Ratcliffe and Christopher Joseph Schofield. These partnerships have enriched her research and expanded the scope of her innovative contributions to the field.
Conclusion
In summary, Kirsty Sarah Hewitson is a leading inventor whose work in hydroxylase modulation holds promise for future medical advancements. Her dedication to innovation and collaboration illustrates the vital role that inventors play in progressing scientific knowledge and improving healthcare solutions. The patents she has developed highlight her impact and commitment to addressing critical health challenges through groundbreaking research.