The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 17, 2010
Filed:
Oct. 16, 2003
Peter John Ratcliffe, Oxford, GB;
Christopher William Pugh, Oxford, GB;
Christopher Joseph Schofield, Oxford, GB;
Kirsty Sarah Hewitson, Oxford, GB;
Jonathan Mark Elkins, Oxford, GB;
Peter John Ratcliffe, Oxford, GB;
Christopher William Pugh, Oxford, GB;
Christopher Joseph Schofield, Oxford, GB;
Kirsty Sarah Hewitson, Oxford, GB;
Jonathan Mark Elkins, Oxford, GB;
Isis Innovation Limited, , GB;
Abstract
A method of identifying, screening, characterising or designing a chemical entity, which mimics or binds to FIH, is described. The method comprises comparing a structural model of FIH with a structural model for said chemical entity, wherein said structural model of FIH is derived from structural factors or structural coordinates determined by subjecting to X-ray diffraction measurements a crystal comprising FIH. Such chemical entities may be used in the treatment of a condition associated with increased or decreased HIF levels or activity.