Location History:
- Gainesville, FL (US) (1991)
- Phoenix, AZ (US) (1992)
- Stanford, CA (US) (1996 - 2002)
- Bethesda, MD (US) (2003 - 2012)
Company Filing History:
4 out of 4 
3 out of 5,309 
2 out of 3,539 
Years Active: 1991-2012
Title: King Chuen Li: Innovator in Nanoparticle Technology
Introduction
King Chuen Li is a prominent inventor based in Bethesda, MD (US). He holds a total of 12 patents that showcase his contributions to the field of nanoparticle technology and gene delivery systems. His innovative work has significant implications for medical applications, particularly in targeted therapies.
Latest Patents
Among his latest patents, one notable invention is the development of targeted cross-linked nanoparticles for in vivo gene delivery. This technology allows for the selective delivery of nucleic acids in a complex with cross-linked nanoparticles, which include neutral and cationic amphipathic molecules. The targeting moiety on the nanoparticles enables precise delivery to specific sites such as blood vessels, endothelial cells, and tumor cells. Another significant patent involves small molecules for imaging protein-protein interactions. This invention facilitates the detection of amyloid deposits and other target proteins in tissues before they aggregate into plaques. The use of a labeled bifunctional compound enhances the imaging process by allowing for the distinction between bound and unbound states of the target proteins.
Career Highlights
King Chuen Li has made substantial contributions to the field through his work at various institutions. He has been associated with Targesome, Inc. and Leland Stanford Junior University, where he has collaborated on groundbreaking research projects. His innovative approaches have led to advancements in the understanding and application of nanoparticle technology in medicine.
Collaborations
Throughout his career, King Chuen Li has worked alongside notable colleagues, including Mark David Bednarski and Henry Y Li. These collaborations have further enriched his research and development efforts in the field of biotechnology.
Conclusion
King Chuen Li's work in nanoparticle technology and gene delivery systems exemplifies the impact of innovation in the medical field. His patents reflect a commitment to advancing scientific knowledge and improving therapeutic strategies.