Kim L R Brouwer

Title: Kim L R Brouwer: Innovator in Hepatocyte Research

Introduction

Kim L R Brouwer is a prominent inventor based in Chapel Hill, NC (US). She has made significant contributions to the field of hepatocyte research, focusing on methods that enhance the understanding of biliary excretion and protein expression in liver cells. With a total of 5 patents, her work has implications for drug development and screening processes.

Latest Patents

Among her latest patents, Brouwer has developed a method for inhibiting the expression of a protein in a hepatocyte. This innovative approach involves screening candidate compounds for their susceptibility to biliary excretion by a hepatocyte transport protein. The method includes introducing RNA sequences that correspond to the coding strand of the gene encoding the transport protein into the hepatocyte, thereby inhibiting its expression. Another notable patent focuses on screening metabolites of parent candidate compounds for susceptibility to biliary excretion. This method entails providing a culture of hepatocytes with at least one bile canaliculus, exposing a candidate compound to the culture, and determining the amount of the compound in the bile canaliculus, which indicates its susceptibility to biliary excretion.

Career Highlights

Brouwer is affiliated with the University of North Carolina at Chapel Hill, where she continues to advance her research in hepatocyte function and drug metabolism. Her work is crucial for understanding how various compounds are processed in the liver, which is essential for developing safer and more effective pharmaceuticals.

Collaborations

Throughout her career, Brouwer has collaborated with esteemed colleagues, including Edward L LeCluyse and Xingrong Liu. These partnerships have fostered a collaborative environment that enhances the research output and innovation in hepatocyte studies.

Conclusion

Kim L R Brouwer's contributions to hepatocyte research and her innovative patents underscore her role as a leading inventor in the field. Her work not only advances scientific understanding but also has practical applications in drug development and screening.