This inventor holds 4 USPTO granted patents. Top assignees: Brown University, Neurotech S.a.. Active years: 2001-2025.
Company Filing History:
Years Active: 2001-2025
Title: Kim Boekelheide: Innovator in Toxicity Testing and Gene Delivery Systems
Introduction
Kim Boekelheide is a notable inventor based in Wakefield, RI (US), recognized for his contributions to the fields of toxicity testing and gene delivery systems. He holds a total of 4 patents, showcasing his innovative approach to addressing complex scientific challenges.
Latest Patents
One of Boekelheide's latest patents is a multi-compartment device containing human three-dimensional (3D) microtissues for toxicity testing. This dual-compartment liver co-culture system exposes target microtissue to metabolites, allowing for evaluating toxicity using a standard multi-well plate for high throughput analysis. Discovery scientists can rapidly select lead compounds with desirable metabolic profiles, while safety scientists can determine the safety of drugs, pesticides, and environmental chemicals. This platform is allometrically scalable, enabling it to mimic the natural size differences between healthy organs and produce sufficient quantities of metabolites. The device is user-friendly and designed for immediate in vitro pathology assessment using confocal microscopy, transcriptomics, and proteomics.
Another significant patent is his polymeric gene delivery system. This invention provides a means for the efficient introduction of exogenous genes into a patient, ensuring long-term expression of the gene. The gene, under the control of an appropriate promoter for expression in a specific cell type, is encapsulated or dispersed with a biocompatible, preferably biodegradable polymeric matrix. This matrix allows the gene to diffuse out over an extended period, typically three to twelve months or longer. The matrix can take various forms, such as microparticles, films, implants, or coatings on devices like stents. The size and composition of the polymeric device are selected to achieve favorable release kinetics in tissue, enhancing the effectiveness of gene transfer.
Career Highlights
Throughout his career, Kim Boekelheide has worked with prominent organizations, including Neurotech S.A. and Brown University. His work has significantly impacted the fields of biotechnology and pharmacology, particularly in developing innovative solutions for drug safety and gene therapy.
Collaborations
He has collaborated with esteemed colleagues, including Edith Mathiowitz and Yong Shik Jong, contributing to advancements in their respective fields.
Conclusion
Kim Boekelheide's innovative work in toxicity testing and gene delivery systems exemplifies the importance of scientific research in improving health