Ken Ng

Title: Ken Ng - Innovator in Biochemical Engineering

Introduction

Ken Ng is a notable inventor based in Calgary, Canada. He has made significant contributions to the field of biochemical engineering, particularly through his innovative work on streptavidin muteins. His research focuses on enhancing the functionality and efficiency of biotin binding, which has important applications in various scientific and medical fields.

Latest Patents

Ken Ng holds a patent for a "Tetrameric streptavidin mutein with reversible biotin binding capability." This invention relates to new streptavidin muteins that are capable of oligomerization to form tetramers. These muteins exhibit relatively strong subunit interactions, with a dissociation constant (K) for biotin in the range of 10 to 10M. The off-rate (k) for the bound biotin in the streptavidin-biotin complex is in the range of 10 seconds. This innovation is stable enough to allow reuse and can be produced with reasonable yield via secretion in a soluble functional state, eliminating the need for the tedious and expensive denaturation and renaturation processes.

Career Highlights

Ken Ng is associated with Uti Limited Partnership, where he continues to advance his research and development efforts. His work has garnered attention for its potential to improve biotechnological applications and enhance the efficiency of biotin-related processes.

Collaborations

Ken has collaborated with esteemed colleagues such as Sui-Lam Wong and Sau-Ching Wu. Their combined expertise has contributed to the success of their projects and innovations in the field.

Conclusion

Ken Ng is a prominent figure in the realm of biochemical engineering, with a focus on innovative streptavidin muteins. His contributions are paving the way for advancements in biotin binding technologies, showcasing the importance of his work in scientific research and application.