This inventor holds 1 USPTO granted patent and 1 published patent application. Top assignee: Jawaharlal Nehru Centre for Advanced Scientific Research. Active years: 2008.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 2008
Title: Innovations of Kempegowda Mantelingu
Introduction
Kempegowda Mantelingu is an accomplished inventor based in Mysore District, India. He has made significant contributions to the field of biochemistry, particularly in the development of novel compounds with potential therapeutic applications. His work focuses on the inhibition of histone acetyltransferases, which play a crucial role in gene regulation.
Latest Patents
Kempegowda Mantelingu holds a patent titled "Polyisoprenylated benzophenones and their isomers as inhibitors of histone acetyltransferases and uses thereof." In this patent, he describes the purification of prenylated benzophenones from the fruit rinds of specific species and evaluates their effectiveness as inhibitors for histone acetyltransferases p300 and PCAF. The findings indicate that these compounds are potent HAT inhibitors, with IC-1 1 μM for p300 and IC-15 15 μM for pCAF. The inhibitors significantly repress p300 HAT-dependent transcriptional activation from in vitro assembled chromatin templates, while having no effect on transcription from DNA. These results suggest that the compounds could be specific to HATs, making them valuable as biological switching molecules for evaluating the roles of p300 and PCAF in cellular functions. Furthermore, they may serve as new chemical entities for the development of anticancer drugs.
Career Highlights
Kempegowda Mantelingu is affiliated with the Jawaharlal Nehru Centre for Advanced Scientific Research, where he conducts his research. His work has garnered attention for its potential implications in cancer treatment and gene regulation.
Collaborations
He has collaborated with notable colleagues, including Kundu Tapas Kumar and Karanam Balasubramanyam, contributing to the advancement of research in his field.
Conclusion
Kempegowda Mantelingu's innovative work in the development of histone acetyltransferase inhibitors highlights the potential for new therapeutic strategies in cancer treatment. His contributions to biochemistry continue to pave the way for future research and applications.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile