Kelcee Everette

Title: Kelcee Everette: Innovator in Prime Editing Technologies

Introduction

Kelcee Everette is a prominent inventor based in Cambridge, MA (US). She has made significant contributions to the field of genetic engineering, particularly in the area of prime editing. Her innovative work has the potential to revolutionize how genetic modifications are conducted.

Latest Patents

Kelcee Everette holds a patent for "Methods and compositions for prime editing nucleotide sequences." This patent describes compositions and methods for conducting prime editing of target DNA molecules, enabling the incorporation of nucleotide changes and targeted mutagenesis. The invention includes fusion proteins that comprise nucleic acid programmable DNA binding proteins (napDNAbp) and a polymerase, guided to specific DNA sequences by a modified guide RNA known as PEgRNA. The PEgRNA has been altered to include an extended portion that provides a DNA synthesis template sequence, which encodes a single-strand DNA flap. This flap is synthesized by the polymerase of the fusion protein and becomes incorporated into the target DNA molecule.

Career Highlights

Throughout her career, Kelcee has worked with esteemed organizations such as the Broad Institute, Inc. and Harvard College. Her experience in these institutions has allowed her to collaborate with leading scientists and contribute to groundbreaking research in genetic engineering.

Collaborations

Kelcee has collaborated with notable researchers, including David R. Liu and Andrew Vito Anzalone. These partnerships have further enhanced her work and expanded the impact of her innovations in the field.

Conclusion

Kelcee Everette is a trailblazer in the realm of prime editing technologies, with her patent and collaborations paving the way for future advancements in genetic engineering. Her contributions are poised to make a lasting impact on the scientific community and beyond.