Keith Robert Willison

Title: Keith Robert Willison: Innovator in Protein Folding Technologies

Introduction

Keith Robert Willison is a notable inventor based in London, GB. He has made significant contributions to the field of protein folding, with a focus on developing binding complexes and folding protein complexes. His work has implications for understanding and manipulating protein functions, which are crucial in various biological processes.

Latest Patents

Willison holds 2 patents that showcase his innovative approaches. His first patent, titled "Binding complexes," relates to binding members capable of interacting with proteins that facilitate the folding of large polypeptides. This invention specifically addresses the chaperone CCT, providing materials and methods to enhance its biological activity within cells. The invention aims to prevent improper folding of CCT substrates such as actin, tubulin, or cyclin by using specific binding members that occupy the CCT substrate binding site.

His second patent, "Folding protein complexes," involves nucleic acid encoding subunits of a polypeptide folding complex containing TCp-1. This complex is useful for promoting the folding of polypeptides, such as tubulin, following recombinant expression. The sequences involved share a high degree of homology, allowing for the development of antibodies that can distinguish between various subunits, which is essential for analyzing and designing complexes that can fold different polypeptides.

Career Highlights

Throughout his career, Willison has worked with prominent organizations, including Cancer Research Campaign Technology Limited and the Institute of Cancer Research: Royal Cancer Hospital. His experience in these institutions has allowed him to contribute to significant advancements in cancer research and protein folding technologies.

Collaborations

Willison has collaborated with esteemed colleagues such as Gillian Hynes and Anthony Kian-Fong Liou. These partnerships have further enriched his research and innovation in the field.

Conclusion

Keith Robert Willison is a distinguished inventor whose work in protein folding technologies has the potential to impact various scientific fields. His patents reflect a deep understanding of protein interactions and their implications for biological processes.