Keith A Otto

Title: Keith A Otto: Innovator in Fusion Protein Technology

Introduction

Keith A Otto is a notable inventor based in Greenwood, IN (US). He has made significant contributions to the field of biotechnology, particularly in the development of fusion proteins that incorporate cell cycle regulatory proteins. His work has implications for various applications in medical and pharmaceutical research.

Latest Patents

Keith A Otto holds a patent for "Fusion proteins comprising cell cycle regulatory proteins." This invention provides novel fusion proteins that include cyclins and cyclin-dependent kinases (CDKs). A preferred embodiment of the invention features fusion proteins comprising human cyclin D1 and human CDK4. The fusion proteins are designed with modifications that facilitate their purification. For instance, the addition of histidine residues allows for purification via immobilized metal affinity chromatography. The invention also includes antigenic determinants for monoclonal antibody-based affinity chromatography purification and protease cleavage sites for further purification processes.

Career Highlights

Keith A Otto has had a distinguished career, working at Eli Lilly and Company, where he has contributed to innovative research and development in biotechnology. His expertise in fusion protein technology has positioned him as a valuable asset in the field.

Collaborations

Some of his notable coworkers include Ramachandra N Rao and Steven Kovacevic, who have collaborated with him on various projects within the company.

Conclusion

Keith A Otto's work in fusion protein technology exemplifies the innovative spirit of modern biotechnology. His contributions continue to influence research and development in the field, showcasing the importance of collaboration and innovation in scientific advancement.