Company Filing History:
4 out of 455 
1 out of 236 
1 out of 194 Years Active: 1993-1999
Title: **Innovative Contributions of Keith A. Diekema**
Introduction
Keith A. Diekema, a notable inventor based in West Chester, Ohio, has made significant contributions to the field of pharmaceuticals through his innovative inventions. With a remarkable portfolio that includes six patents, his work primarily focuses on compounds that target critical biological processes.
Latest Patents
Among his latest patents, Diekema has developed **alkyloxyamino substituted fluorenones**, which inhibit protein kinase C. This invention encompasses pharmaceutical compositions that utilize these compounds to regulate protein kinase C activity in mammals, including humans. Such advancements offer promising applications for the treatment of neoplastic diseases, disorders associated with abnormal blood flow (like hypertension and atherosclerosis), and various inflammatory diseases such as asthma and psoriasis.
Another significant invention by Diekema pertains to **calcium uptake inhibitors**, specifically 1-aryl-3-pyridinyl-2-propene-1-ones. This patent pertains to the use of these compounds as calcium uptake inhibitors in leukocytes and thrombocytes, along with associated pharmaceutical compositions. This discovery enhances the therapeutic options available for diseases related to calcium signaling.
Career Highlights
Diekema's career has seen collaboration with prominent companies in the pharmaceutical industry, notably **Merrell Dow Pharmaceuticals** and **Hoechst Marion Roussel**. His experience in these reputable organizations has helped shape his expertise and innovation in developing effective pharmaceutical solutions.
Collaborations
Throughout his career, Keith A. Diekema has worked alongside esteemed colleagues, including Robert J. Dinerstein and Jeffrey Sabol. This collaborative environment has undoubtedly fostered a greater exchange of ideas, leading to the successful development of his innovative patents.
Conclusion
Overall, Keith A. Diekema's contributions to innovation and invention within the pharmaceutical sector underscore his role as an influential inventor. His patented compounds, which target vital biological pathways, reflect the potential impact of his work on medical treatments and the improvement of health conditions. As the field continues to evolve, Diekema's legacy as an inventor will undoubtedly pave the way for further advancements.