Keiko Kasutani

Title: Keiko Kasutani: Innovator in Therapeutic Antibodies

Introduction

Keiko Kasutani is a prominent inventor based in Shizuoka, Japan. She has made significant contributions to the field of therapeutic antibodies, particularly in the treatment of inflammatory diseases. With a total of 5 patents to her name, her work has garnered attention for its potential clinical applications.

Latest Patents

One of her latest patents involves antibodies that bind to the cytokine receptor NR10. The inventors obtained an anti-mouse NR10 neutralizing antibody-expressing BM095 clone from a phage library of human antibodies. This clone demonstrates strong proliferation-suppressing activity in an IL-31-dependent Ba/F3 cell proliferation assay system. When administered to NC/Nga mice, a model for atopic dermatitis, significant symptom suppression was observed. This finding indicates that the anti-NR10 neutralizing antibody could serve as an effective therapeutic agent for inflammatory diseases. Additionally, the inventors successfully developed an anti-human NR10 neutralizing antibody, which holds promise for practical clinical applications.

Career Highlights

Keiko Kasutani has established herself as a key figure in her field through her innovative research and development efforts. Her work at Chugai Seiyaku Kabushiki Kaisha has been instrumental in advancing therapeutic options for patients suffering from chronic inflammatory conditions.

Collaborations

Throughout her career, she has collaborated with notable colleagues, including Hidetomo Kitamura and Masakazu Hasegawa. These partnerships have further enhanced the impact of her research and contributed to the success of her projects.

Conclusion

Keiko Kasutani's contributions to the field of therapeutic antibodies exemplify her dedication to innovation and improving patient outcomes. Her work continues to pave the way for new treatments in inflammatory diseases, showcasing the importance of research and collaboration in the medical field.