Keietsu Abe

Title: Keietsu Abe: Innovator in Biochemical Engineering

Introduction

Keietsu Abe is a prominent inventor based in Noda, Japan. He has made significant contributions to the field of biochemical engineering, particularly in the development of transport proteins and metabolic energy systems. With a total of 5 patents, his work has implications for both industrial applications and pharmaceutical advancements.

Latest Patents

One of Abe's latest patents is focused on the OxlT sequence and its use. This invention provides a DNA sequence encoding a transport protein responsible for the physical movement of oxalate and formate across the plasma membrane. The protein, known as OxlT, can be isolated from the gram-negative anaerobe, Oxalobacter formigenes. This protein is part of a three-protein oxalate/formate antiport exchange system that facilitates the conversion of extracellular oxalate to formate and carbon dioxide. The OxlT coding sequence can be utilized to create a metabolic energy system within cells, which includes the OxlT transport protein in conjunction with oxalyl-CoA decarboxylase and formyl-CoA transferase. Such energy-generating systems can enhance culture longevity and increase product yield in industrial fermentation settings. Additionally, the OxlT coding sequence has potential applications in pharmaceutical compositions aimed at manipulating serum oxalic acid levels in patients, with the possibility of developing liposomes for administration to humans and other animals.

Another notable patent involves the leucine aminopeptidase gene from Aspergillus sojae. This invention encompasses the gene or its variants, a recombinant DNA that includes the gene, and a process for producing leucine aminopeptidase using the recombinant DNA.

Career Highlights

Throughout his career, Keietsu Abe has worked with esteemed organizations such as Kikkoman Corporation and The Johns Hopkins University. His experience in these institutions has allowed him to collaborate on various innovative projects that push the boundaries of biochemical research.

Collaborations

Abe has collaborated with notable colleagues, including Kinji Uchida and Hironaga Hashiba. Their combined expertise has contributed to the advancement of their respective fields and the successful development of innovative solutions.

Conclusion

Keietsu Abe's contributions to biochemical engineering through his patents and collaborations highlight his role as a significant inventor in the field. His work not only advances scientific understanding but