This inventor holds 2 USPTO granted patents. Top assignee: Alpha Therapeutic Corporation. Active years: 1997-1999.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 1997-1999
Title: Kazuo Takechi: Innovator in Protein Purification
Introduction
Kazuo Takechi is a notable inventor based in Arcadia, CA (US). He has made significant contributions to the field of protein purification, holding 2 patents that showcase his innovative approaches. His work primarily focuses on enhancing the yield and purity of alpha-1-proteinase inhibitor (alpha-1-PI).
Latest Patents
Kazuo Takechi's latest patents include a process for increasing the yield of a protein that has been subjected to purification. This process involves providing an impure protein fraction containing alpha-1-PI, which is suspended in an aqueous solution at pH 6. Insoluble proteins are recovered and resuspended in an aqueous solution at pH 8.5. Polyethylene glycol (PEG) is added to precipitate alpha-2 proteins. Subsequently, zinc chloride (ZnCl2) is introduced to the PEG supernatant, leading to the precipitation of crude alpha-1-PI. The crude alpha-1-PI is then resolubilized and applied to an anion-exchange medium, from which a fraction comprising alpha-1-PI is recovered. The purified alpha-1-PI exhibits a specific activity of about 1.0 units/OD280.
Another significant patent by Takechi is a process for separating alpha-1-proteinase inhibitor from COHN IV1. This process follows a similar methodology, emphasizing the purification of alpha-1-PI from impure protein fractions.
Career Highlights
Kazuo Takechi is currently associated with Alpha Therapeutic Corporation, where he continues to advance his research in protein purification. His innovative techniques have the potential to impact various applications in biotechnology and medicine.
Collaborations
Throughout his career, Kazuo Takechi has collaborated with notable colleagues, including Mark Lepe and Lyndon Luz. These collaborations have contributed to the development and refinement of his patented processes.
Conclusion
Kazuo Takechi's work in protein purification exemplifies the spirit of innovation in the field of biotechnology. His patents reflect a commitment to enhancing the efficiency and effectiveness of protein purification processes.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile