Kay M Parkhurst

Title: Kay M Parkhurst: Innovator in DNA Mutation Detection

Introduction

Kay M Parkhurst is a distinguished inventor based in Lincoln, NE (US). She has made significant contributions to the field of molecular biology, particularly in the detection of point mutations in DNA. With a total of 2 patents, her work has the potential to enhance genetic research and diagnostics.

Latest Patents

Kay M Parkhurst's latest patents focus on a method for detecting point mutations in DNA utilizing fluorescence energy transfer. This innovative approach employs a fluorescently labeled oligomeric probe and Forster resonance energy transfer (FRET). The probe is labeled at both ends with fluorescence dyes that function as a donor/acceptor pair for FRET. The fluorescence emission from these dyes changes significantly when the probe is hybridized to the complementary DNA strand compared to when it is detached. This change in fluorescence, which varies with temperature, allows for the calculation of the melting temperature of the DNA complex. In cases of base mismatches, indicating point mutations, the melting temperature is notably lower than that of a perfectly matched probe/strand duplex. This invention facilitates the quick and accurate detection of point mutations and can help determine their approximate location within the DNA sequence.

Career Highlights

Kay M Parkhurst is affiliated with the University of Nebraska, where she continues her research and development in the field of genetics. Her work has garnered attention for its practical applications in medical diagnostics and genetic research.

Collaborations

Kay has collaborated with notable colleagues, including Lawrence J Parkhurst and Lyle R Middendorf, contributing to advancements in her field.

Conclusion

Kay M Parkhurst's innovative work in DNA mutation detection exemplifies the impact of scientific research on healthcare and genetics. Her contributions are paving the way for more accurate and efficient methods of genetic analysis.