Company Filing History:
Years Active: 1998-2001
Title: **Kathleen K. Bierilo: Pioneering Innovations in Biochemistry**
Introduction
Kathleen K. Bierilo is an accomplished inventor based in Matawan, New Jersey. With a focus on biochemistry, she has made significant contributions to the field, evidenced by her three patents. Her work primarily revolves around the cloning and characterization of bradykinin receptors, which play an essential role in various physiological processes.
Latest Patents
Kathleen's latest inventions include groundbreaking work on bradykinin B1 receptor antibodies. In her first patent, she describes the cloning and characterization of DNAs encoding bradykinin B1 receptors from mammalian cells. The recombinant receptor formed is capable of binding to des-Arg kallidin and other B1-specific ligands. This DNA has been successfully expressed in recombinant host cells, which produce active recombinant proteins. Furthermore, these cells are utilized to develop methods to identify modulators of receptor activity.
In another patent, Kathleen again focuses on bradykinin B1 receptors, detailing the cloning and characterization of purified bradykinin B1 receptors. The expressed DNA has resulted in recombinant proteins that maintain similar binding capabilities to des-Arg10 kallidin and other B1-specific ligands, continuing to advance the understanding of this critical receptor's functionality.
Career Highlights
Kathleen is employed at Merck & Company, Inc., a leading global healthcare company committed to improving health and well-being. Throughout her career, her innovative work has earned her recognition in the field of biochemistry, particularly in the area of receptor research.
Collaborations
Throughout her journey, Kathleen has collaborated with esteemed colleagues, including David L. Linemeyer and John W. Hess. These collaborations have facilitated the sharing of knowledge and expertise, further enhancing the quality and impact of her research.
Conclusion
Kathleen K. Bierilo exemplifies the innovative spirit of today’s scientific researchers. Her significant contributions through her patents have the potential to influence the field of biochemistry profoundly. With her dedication to advancing our understanding of receptor functionalities, she continues to pave the way for future discoveries and innovations.