Company Filing History:
14 out of 16 
10 out of 1,635 
1 out of 68 
Years Active: 2001-2013
Title: Innovations and Contributions of Kathleen D. Danenberg
Introduction
Kathleen D. Danenberg, based in Altadena, California, is a notable inventor with a significant portfolio of 26 patents. Her work primarily focuses on developments in the field of cancer treatment and genomic analysis. Danenberg's inventions contribute valuable insights into personalized medicine and high-throughput genetic research.
Latest Patents
Among her latest contributions is a patent for a method of determining a chemotherapeutic regimen based on ERCC1 and TS expression. This invention relates to prognostic methods in medicine, especially concerning cancer chemotherapy. It provides a technique for assessing TS and/or ERCC1 expression levels in fixed or paraffin-embedded tissues. The objective is to prognosticate the probable resistance of a patient's tumor to treatment with 5-FU and oxaliplatin-based therapies by analyzing the levels of TS and/or ERCC1 mRNA in tumor cells and comparing them to predetermined threshold levels.
Another significant patent from Danenberg pertains to a process for high-throughput DNA methylation analysis. This improved quantitative method allows for the determination of methylation patterns in genomic DNA samples through amplification-dependent displacement of hybridization probes. By treating genomic DNA with sodium bisulfite, it creates methylation-dependent sequence differences that can be rapidly analyzed, making it particularly effective for analyzing large volumes of tumor tissue samples.
Career Highlights
Kathleen has held pivotal roles in companies that emphasize genetic research and innovation, notably at Response Genetics, Inc. and the University of Southern California. Her experience in these institutions has enabled her to enhance methodologies in cancer genomics and personalized medicine.
Collaborations
Over the course of her career, Danenberg has collaborated with esteemed professionals such as Peter V. Danenberg and Steven Swenson. These partnerships have fostered a rich exchange of ideas and advancements that further enhance her contributions to the field.
Conclusion
Kathleen D. Danenberg's innovative spirit and commitment to advancing cancer treatment through her inventions make her a significant figure in the realm of medical research. Her patents not only demonstrate her expertise but also pave the way for future advancements in personalized medicine and genomic analysis, ultimately aiming to improve patient outcomes in cancer therapy.