Kathleen A Clark

Title: Innovations in Nucleic Acid Extraction by Kathleen A Clark

Introduction

Kathleen A Clark is a prominent inventor based in Cardiff by the Sea, California. She has made significant contributions to the field of molecular biology, particularly in the extraction of nucleic acids from various organisms. With a total of 3 patents, her work has paved the way for advancements in research and clinical diagnostics.

Latest Patents

One of her latest patents focuses on methods for extracting nucleic acids by heating sample cells at about 80-95 degrees Celsius in a permeabilization reagent containing a non-ionic detergent and a metal chelating agent. This innovative method allows for the release of large fragments of undegraded nucleic acids without physically disrupting the entire cell wall. The nucleic acids are released into solution without bursting the cells, making them suitable for research and testing without further purification. The extraction method is rapid, easy to perform, and applicable to a wide variety of cells, including microorganisms. Additionally, clinical samples can be screened for the presence or absence of a microorganism using this method, which includes the use of a nucleic acid probe specific to the selected microorganism.

Career Highlights

Kathleen A Clark is associated with Gen-Probe, Inc., where she has been instrumental in developing innovative techniques for nucleic acid extraction. Her work has significantly impacted the field, enhancing the efficiency and effectiveness of nucleic acid testing.

Collaborations

Some of her notable coworkers include Daniel L Kacian and Diane L McAllister, who have collaborated with her on various projects related to nucleic acid extraction and molecular diagnostics.

Conclusion

Kathleen A Clark's contributions to the field of nucleic acid extraction have been groundbreaking. Her innovative methods continue to influence research and clinical practices, showcasing her role as a leading inventor in this vital area of science.