This inventor holds 3 USPTO granted patents and 5 published patent applications and 1 EPO patent. Top assignee: Regeneron Pharmaceuticals, Inc.. Active years: 2019-2026.
Company Filing History:
Years Active: 2019-2026
Title: Innovations by Kathir Muthusamy in Protein Purity Determination
Introduction
Kathir Muthusamy is an accomplished inventor based in Cheshire, CT (US). He has made significant contributions to the field of biochemistry, particularly in the area of protein purity determination. With a total of 3 patents, his work focuses on improving methods for the detection and quantification of specific molecular entities.
Latest Patents
Muthusamy's latest patents include advancements in multimeric protein purity determination. He has developed improved capillary zone electrophoresis (CZE), affinity capillary electrophoresis (ACE), and partially filled-ACE (PF-ACE) systems. These systems provide methods for detecting and quantifying specific molecular entities in complex mixtures. His work addresses the challenges faced during the manufacturing of heterodimeric bispecific antibodies, which are often produced alongside homodimer species. This can complicate the quantification of the bispecific antibody. Muthusamy's innovations include capillary electrophoretic systems and methods for detecting specific homodimers in mixtures of bispecific heterodimers and homodimers. By using a ligand that binds to one of the subunits of the bispecific antibody, he enables the formation of a complex with reduced electrophoretic mobility, facilitating the detection of unbound homodimers.
Career Highlights
Kathir Muthusamy is currently employed at Regeneron Pharmaceuticals, Inc., where he continues to advance his research in biochemistry and protein analysis. His work has been instrumental in enhancing the accuracy of protein quantification methods, which is crucial for the development of therapeutic antibodies.
Collaborations
Muthusamy has collaborated with notable colleagues, including Jiann Kae Luo and Jiann-Kae Luo, contributing to a dynamic research environment that fosters innovation and discovery.
Conclusion
Kathir Muthusamy's contributions to the field of protein purity determination exemplify the impact of innovative research in biochemistry. His patents reflect a commitment to improving analytical methods that are essential for the development of biopharmaceuticals.