This inventor holds 2 USPTO granted patents and 1 published patent application. Top assignee: New England Biolabs, Inc.. Active years: 2025.
Company Filing History:
Years Active: 2025
Title: Katharina Bilotti: Innovator in DNA Assembly Technologies
Introduction
Katharina Bilotti is a prominent inventor based in Burlington, MA (US). She has made significant contributions to the field of biotechnology, particularly in the area of DNA assembly technologies. With a total of 2 patents, her work has advanced the methods used for assembling DNA fragments, which is crucial for various applications in genetic engineering and synthetic biology.
Latest Patents
Katharina's latest patents include innovative compositions and methods for improved in vitro assembly of polynucleotides. One of her notable inventions is the "Ordered assembly of multiple DNA fragments," which provides a synthetic self-complementary oligonucleotide that features a double-stranded region and a loop. This oligonucleotide is designed to include unligatable 3' and 5' ends that cannot be cleaved by the Type IIS restriction endonuclease PaqCI. The kit associated with this invention contains the oligonucleotide and the endonuclease, facilitating efficient DNA assembly.
Another significant patent is focused on "Compositions and methods for improved in vitro assembly of polynucleotides." This invention enhances the frequency and fidelity of assembling large numbers of DNA fragments into a single large DNA molecule. By utilizing a computer system that integrates comprehensive ligation data, Katharina's methods optimize synthetic overhangs for assembly by ligation, avoiding intragenic cut sites and providing precision in assembly reactions.
Career Highlights
Katharina Bilotti is currently employed at New England Biolabs, Inc., where she continues to innovate in the field of molecular biology. Her work has been instrumental in developing new techniques that streamline the process of DNA assembly, making it more efficient and reliable.
Collaborations
Throughout her career, Katharina has collaborated with notable colleagues, including Gregory Lohman and Vladimir Potapov. These collaborations have further enriched her research and contributed to the advancements in DNA assembly technologies.
Conclusion
Katharina Bilotti's contributions to the field of biotechnology, particularly in DNA assembly, have established her as a leading inventor. Her innovative patents and ongoing work at New England Biolabs, Inc. continue to influence the landscape of genetic engineering and synthetic biology.