Kaspar-Philip Holliger

Title: Innovations of Kaspar-Philip Holliger

Introduction

Kaspar-Philip Holliger is a notable inventor based in Cambridge, GB. He has made significant contributions to the field of biotechnology, particularly in the development of binding proteins. His work has implications for various applications in medical research and therapeutic development.

Latest Patents

Holliger holds a patent for "Multivalent and multispecific binding proteins and their use." This patent describes polypeptides that comprise a first domain, which includes a binding region of an immunoglobulin heavy chain variable region, and a second domain, which includes a binding region of an immunoglobulin light chain variable region. The domains are linked but are incapable of associating with each other to form an antigen binding site. Instead, they associate to form antigen binding multimers, such as dimers, which may be multivalent or have multispecificity. The domains can be linked by a short peptide linker or may be joined directly together, with bispecific dimers potentially having longer linkers. The patent also discloses methods of preparation for the polypeptides and multimers, as well as their display on the surface of bacteriophage for easy selection of binders of interest, along with various utilities.

Career Highlights

Holliger is affiliated with the Medical Research Council, where he continues to advance his research in binding proteins. His innovative work has positioned him as a key figure in the field of immunology and protein engineering.

Collaborations

He has collaborated with notable colleagues, including Andrew David Griffiths and Hendricus Renerus Jacobus Matheus Hoogenboom, contributing to the advancement of their shared research interests.

Conclusion

Kaspar-Philip Holliger's contributions to the field of biotechnology through his innovative patents and collaborations highlight his importance as an inventor. His work continues to influence the development of new therapeutic strategies.