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For the Inventor, By the Inventor

Budapest, Hungary

Karola Jovanovics

USPTO Granted Patents = 11

Average Co-Inventor Count = 5.1

ph-index = 4

Forward Citations = 32(Granted Patents)


Company Filing History:

goldMedal11 out of 346 
 
Richter Gedeon Vegyeszeti Gyar Rt
 patents

Years Active: 1977-1982

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11 patents (USPTO):Explore Patents
1. 4310528 - Process for the preparation of bis-indole alkaloids and acid-addition (1982-01-12),
2. 4298525 - Bis-indole-alkaloid (1981-11-03),
3. 4279916 - Method of treatment using new leurosine derivatives (1981-07-21),
4. 4279915 - Method of treatment using new leurosine derivatives (1981-07-21),
5. 4279816 - N-Formyl leurosine derivatives in a dosage form effective for treating (1981-07-21),
6. 4209443 - Process for separating pharmaceutically active diindole alkaloids (1980-06-24),
7. 4199505 - Process for the preparation of alkaloids of the leurosine type (1980-04-22),
8. 4189432 - N-formyl and N-desmethyl leurosine derivatives (1980-02-19),
9. 4172077 - Process for the isolation of alkaloid components from the plant Vinca (1979-10-23),
10. 4070358 - Process for the preparation of diindole alkaloids or of the acid (1978-01-24),
11. 4065458 - Eburnamenine derivatives (1977-12-27),

Title: The Innovative Contributions of Karola Jovanovics

Introduction

Karola Jovanovics is a prominent inventor based in Budapest, Hungary. She has made significant contributions to the field of chemistry, particularly in the development of bis-indole alkaloids with antitumor properties. With a total of 11 patents to her name, her work has garnered attention in both academic and industrial circles.

Latest Patents

Among her latest patents is a process for the preparation of bis-indole alkaloids and acid-addition. This innovative process focuses on creating diindole-alkaloids, specifically new compounds that correspond to vinblastine or leurosine. In this method, the N-methyl group is replaced by an N--CH.sub.2 --O--R group, where R is a lower alkyl, which has demonstrated antitumor properties. The starting materials undergo oxidation using chromic acid or an alkali metal dichromate at temperatures ranging from -90°C to -30°C, preferably below -45°C, in the presence of a lower alkanol. Another notable patent involves a similar process for producing diindolealkaloids, where the N-methyl group is replaced by an N--CH.sub.2 --OC.sub.2 H.sub.5 group, also exhibiting antitumor properties.

Career Highlights

Karola Jovanovics is currently employed at Richter Gedeon Vegyeszeti Gyar Rt., a leading pharmaceutical company in Hungary. Her work at this esteemed institution has allowed her to further her research and development in the field of medicinal chemistry.

Collaborations

Throughout her career, Jovanovics has collaborated with notable colleagues, including Kalman Szasz and Csaba Lorincz. These partnerships have contributed to the advancement of her research and the successful development of her patented processes.

Conclusion

Karola Jovanovics stands out as a significant figure in the field of chemistry, with her innovative patents paving the way for advancements in antitumor treatments. Her contributions continue to impact the pharmaceutical industry positively.

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