Company Filing History:
Years Active: 2002-2003
Title: Innovations of Karl H Hecker
Introduction
Karl H Hecker is a notable inventor based in Milpitas, CA (US). He has made significant contributions to the field of biotechnology, particularly in the area of DNA separation and cDNA library preparation. With a total of three patents to his name, Hecker's work has advanced the methodologies used in genetic research and analysis.
Latest Patents
Hecker's latest patents include a "Column for DNA separation by matched ion polynucleotide chromatography." This invention presents an improved separation column and method for separating a mixture of double-stranded DNA fragments. The cylindrical column features an internal diameter greater than about 5 mm and contains polymer beads. These beads have an average diameter ranging from 1 to 100 microns and are either unsubstituted or substituted with hydrocarbon moieties. The column enhances the separation of DNA fragments sized from about 100 to 20,000 base pairs and is particularly effective in mutation detection procedures.
Another significant patent is the "Method and system for the preparation of cDNA." This invention outlines an improved method for generating cDNA libraries, focusing on enriching high molecular weight cDNA inserts. The method involves size-based separation of mRNA molecules using Ion-Pairing Reversed-Phase Chromatography (IP-RPC) under denaturing conditions. The collected mRNA fraction can then be reverse transcribed to form a library of cDNA inserts enriched for desired size ranges.
Career Highlights
Hecker has been instrumental in advancing biotechnological methods through his innovative patents. His work at Transgenomic, Inc. has positioned him as a key figure in the field, contributing to the development of tools that enhance genetic research.
Collaborations
Hecker has collaborated with notable colleagues such as Douglas T Gjerde and Robert M Haefele, further enriching the research environment and fostering innovation.
Conclusion
Karl H Hecker's contributions to biotechnology through his patents have significantly impacted the field of genetic research. His innovative methods for DNA separation and cDNA library preparation continue to influence advancements in the industry.