Location History:
- Gaithersburg, MD (US) (1990)
- Chevy Chase, MD (US) (1990 - 1996)
- Wynnewood, PA (US) (1999 - 2003)
Company Filing History:
7 out of 100 
3 out of 8 
2 out of 33 Years Active: 1990-2003
Title: The Innovations of Karl D Hardman
Introduction
Karl D Hardman is a notable inventor based in Gaithersburg, MD, who has made significant contributions to the field of biochemistry and protein engineering. With a remarkable portfolio of 12 patents, Hardman's work primarily focuses on the development of multivalent antigen-binding proteins, which have vast applications in both therapeutic and diagnostic fields. His innovative approaches to protein purification and assembly have opened new avenues in medical research.
Latest Patents
Among Karl D Hardman's latest patents is a groundbreaking invention related to multivalent antigen-binding proteins. This patent describes the compositions, genetic constructions coding for, and methods for producing these proteins. The methods include purification techniques that manage both monomeric and multivalent forms of single polypeptide chain molecules. Notably, the production process can occur via a concentration-dependent association of monomeric proteins or through rearrangements involving dissociation and reassociation of specific regions. His work also includes the creation of bivalent proteins, both homobivalent and heterobivalent, with disclosed genetic sequences for bivalent single-chain antigen-binding proteins. The applications of these proteins extend to all functions relevant for monoclonal and polyclonal antibodies and fragments, particularly as bispecific antigen-binding molecules.
Career Highlights
Karl D Hardman's career features significant tenures at reputable organizations such as Enzon Inc. and Enzon Labs Inc. His experiences in these companies have enhanced his expertise and allowed him to collaborate with leading minds in the field. His innovative spirit has consistently driven advancements in the understanding and application of antibody technologies, directly impacting the development of novel therapeutic strategies.
Collaborations
Throughout his career, Hardman has collaborated with esteemed colleagues, including Robert E Bird and Marc D Whitlow. These partnerships have been instrumental in furthering research and development in protein engineering, enabling a collective push towards achieving cutting-edge solutions in biotechnology.
Conclusion
Karl D Hardman's contributions to the field of protein engineering cannot be overstated. His inventive spirit and dedication to research have established him as a significant figure in the development of multivalent antigen-binding proteins. As the scientific community continues to explore the potential of his patented inventions, the impact of his work will likely resonate in therapeutic and diagnostic innovations for years to come.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.