K Bruce Jacobson

Title: K Bruce Jacobson: Innovator in Micromechanical Sensors and DNA Diagnostics

Introduction

K Bruce Jacobson is a notable inventor based in Oak Ridge, TN (US), recognized for his contributions to the fields of micromechanical sensors and DNA diagnostics. With a total of 4 patents, Jacobson has made significant advancements that have the potential to impact various scientific and medical applications.

Latest Patents

One of Jacobson's latest patents is the micromechanical antibody sensor. This innovative sensor apparatus utilizes a microcantilevered spring element coated with a detector molecule, such as an antibody or antigen. When a sample containing a target molecule is introduced, the spring element bends in response to the binding stress between the detector and target molecules. The deflections of the cantilever are detected using various techniques, with the microcantilever dimensions ranging from approximately 1 to 200 µm in length, 1 to 50 µm in width, and 0.3 to 3.0 µm in thickness. The sensitivity for detecting deflections is in the range of 0.01 nanometers.

Another significant patent involves DNA sequencing, mapping, and diagnostic processes using hybridization. This process leverages the differences in chemical composition between DNA and peptide nucleic acids (PNAs) to facilitate DNA sequencing and diagnostics without the need for radioisotopes or fluorescent labels. The method includes hybridizing PNA segments to complementary DNA segments fixed to a hybridization surface, or vice versa, and analyzing the extent of hybridization using mass spectrometric or non-mass spectrometric techniques.

Career Highlights

Throughout his career, Jacobson has worked with several prominent organizations, including Atom Sciences, Inc. and UT-Battelle, Inc. His work in these companies has contributed to the development of innovative technologies in the fields of biotechnology and materials science.

Collaborations

Jacobson has collaborated with esteemed colleagues such as Heinrich F. Arlinghaus and Thomas George Thundat. These partnerships have fostered a collaborative environment that has led to significant advancements in their respective fields.

Conclusion

K Bruce Jacobson's innovative work in micromechanical sensors and DNA diagnostics showcases his commitment to advancing technology in science and medicine. His patents reflect a deep understanding of complex biological processes and a dedication to improving diagnostic methods. Jacobson's contributions continue to