Justin M Keen

Title: The Innovative Contributions of Justin M Keen

Introduction

Justin M Keen is a notable inventor based in Austin, TX (US). He has made significant contributions to the field of pharmaceutical compositions, particularly in the stabilization of alkaline labile drugs. With a total of 5 patents to his name, Keen's work has the potential to enhance drug delivery systems and improve patient outcomes.

Latest Patents

One of Keen's latest patents focuses on stabilized compositions containing alkaline labile drugs. This invention provides a stabilized bioadhesive composition that includes an alkaline labile drug and a method for its preparation. The composition is a hot-melt extruded (HME) formulation that comprises a preformed excipient mixture containing an acidic component and an alkaline thermoplastic matrix-forming material, such as a polymer. The excipient mixture is created before blending with the alkaline labile drug, and the blend is then hot-melt extruded to form the final HME composition. This innovative process allows the acidic component to neutralize or moderately acidify the excipient mixture, significantly reducing the degradation of the alkaline labile drug during hot-melt extrusion. The excipient mixture softens or melts during the extrusion process, which can either dissolve or not dissolve drug-containing particles. Various functional excipients can be incorporated into the carrier system to enhance process performance and improve the chemical or physical properties of the HME composition.

Career Highlights

Justin M Keen is currently associated with Auxilium US Holdings, LLC, where he continues to develop innovative solutions in the pharmaceutical industry. His expertise in drug formulation and stabilization has positioned him as a valuable asset in his field.

Collaborations

Keen has collaborated with notable colleagues, including Michael Crowley and John Joseph Koleng, Jr. These partnerships have contributed to the advancement of his research and the successful development of his patents.

Conclusion

Justin M Keen's contributions to the field of pharmaceutical compositions demonstrate his commitment to innovation and improving drug delivery systems. His work has the potential to significantly impact patient care and the pharmaceutical industry as a whole.