Company Filing History:
Years Active: 2010-2013
Title: Innovations by Julie A Dohm: Pioneering Anti-HIV and Anti-Cancer Agents
Introduction
Julie A Dohm is an accomplished inventor based in Oak Lawn, IL (US). She has made significant contributions to the field of medicinal chemistry, particularly in the development of new compounds with potential therapeutic applications. With a total of two patents to her name, her work focuses on innovative solutions to combat serious health issues such as HIV and cancer.
Latest Patents
Dohm's latest patents include the development of heterocyclic and carbonate derivatives of nordihydroguaiaretic acid (NDGA) and their use as new anti-HIV and anti-cancer agents. The reaction of NDGA with various alkyl chlorides, 1-piperidinecarbonyl chloride, methyl chloroformate, or 1,1'-carbonyldiimidazole under alkaline conditions produced corresponding phenol ethers, carbamates, and carbonates in yields ranging from 67% to 83%. Among these derivatives, nitrogen-containing compounds were converted to hydrochloride salts, demonstrating good solubility and stability in aqueous solutions. These new compounds exhibited potent activities against HIV Tat-regulated transactivation in cos-7 cells. The most active transcription inhibitor compound from this series, identified as 5b (PN, Tetrapiperidino NDGA, meso-2,3-dimethyl-1,4-bis(3,4-[2-(piperidino)ethoxyphenyl])butane tetrakishydrochloride salt), has an IC of 0.88 µ.
Career Highlights
Julie A Dohm is affiliated with The Johns Hopkins University, where she continues her research and development efforts. Her work has garnered attention for its potential impact on public health, particularly in the fight against HIV and cancer.
Collaborations
Dohm has collaborated with notable colleagues, including Ru Chih C Huang and Apostolos Gittis, to advance her research initiatives. These collaborations have contributed to the successful development of her innovative compounds.
Conclusion
Julie A Dohm's contributions to the field of medicinal chemistry highlight her dedication to developing new therapeutic agents. Her innovative work in creating anti-HIV and anti-cancer compounds showcases the potential of her research to make a significant impact on health outcomes.