Juergen Helfman

Title: Juergen Helfman: Innovator in Molecular Analysis

Introduction

Juergen Helfman is a notable inventor based in Kleinmachnow, Germany. He has made significant contributions to the field of molecular analysis, holding 2 patents that showcase his innovative approach to investigating substance libraries and analyzing molecular reaction products in biological cells.

Latest Patents

One of his latest patents is a method and device for investigating substance libraries. The aim of this invention is to explore the bonding of substances to target molecules. This is achieved through a densely packed device that allows various target molecules to be bonded in numerous sample areas. The design minimizes cross-contamination and evaporation while maximizing the active surface of the sample areas. The solution involves using carrier plates with densely packed capillary structures, which can bond 1000 times more molecules than a flat surface of comparable size. The lack of cross links between the capillaries prevents cross-contamination, and the small outer surface reduces evaporation. After silanizing the inner surface of the capillaries, peptides and peptidomimetics can be synthesized in a targeted manner. The molecular interactions of the substance library components with active substances in a solution or suspension are investigated using a local resolution optical detection method.

Another significant patent by Helfman is a method and device for analyzing molecular reaction products in biological cells. This invention allows for the evaluation of a large number of cells regarding their reaction state with molecular reactants under near-field optical conditions. The measuring and evaluation procedure utilizes light sources of varying aperture diameters in the nano- or micro-range, arranged in a sample platform. The 2D-nano-light source array consists of multiple near-field light sources that are positioned in a raster form and can be excited jointly or in succession. The carrier material used in this invention is a semiconductor material.

Career Highlights

Juergen Helfman has worked with Laser- und Medizin Technologie GmbH, where he contributed to advancements in medical technology. His experience in this company has helped him develop innovative solutions in molecular analysis.

Collaborations

Throughout his career, Helfman has collaborated with notable individuals such as Gerhard H. Mueller and Andreas Frey. These collaborations have further enriched his work and contributed to his success as an inventor.

Conclusion

Juergen Helfman is a distinguished inventor whose work in molecular analysis has led to significant advancements in the