Jue Lin

Title: Innovations of Jue Lin in Telomere Research

Introduction

Jue Lin is an accomplished inventor based in Foster City, California, known for his significant contributions to the field of telomere research. With a total of three patents to his name, Lin has developed innovative methods that enhance the understanding of telomere abundance and its implications in various biological contexts.

Latest Patents

One of Lin's latest patents is titled "Measures of Short Telomere Abundance." This invention provides methods and materials for measuring telomere abundance from chromosomes in a sample that contains telomeres within a predetermined length range. The methods involve a time-limited extension reaction calibrated to produce extension products from a double-stranded chromosomal DNA template of no more than a defined length. Following this, a second step amplifies sequences bounded by a sub-telomeric sequence and an anchor sequence, resulting in a length-limited telomere sequence product. The abundance of telomeric sequences in this product can be measured and correlated to various indices.

Another notable patent is "Multiplex Quantitative PCR." This invention discloses methods and compositions for determining the average length or abundance of a first target nucleic acid by calculating its abundance relative to the average abundance of second and third target nucleic acids, all within a single well using separate detection labels. In many cases, the first target nucleic acid is a telomere. The methods can be utilized to determine the average telomere length in a biological sample, which can then be correlated to clinically important conditions and indices.

Career Highlights

Throughout his career, Jue Lin has worked with notable organizations, including Telomere Diagnostics, Inc. and the University of California. His work has significantly advanced the understanding of telomeres and their role in health and disease.

Collaborations

Lin has collaborated with esteemed colleagues such as Calvin B Harley and Yajing Hu, contributing to the advancement of research in telomere biology.

Conclusion

Jue Lin's innovative patents and research contributions have made a lasting impact in the field of telomere research, providing valuable tools for understanding the biological significance of telomeres. His work continues to influence the scientific community and pave the way for future discoveries.