Judy L Bolton

Title: Innovations in Drug Metabolism: The Contributions of Judy L. Bolton

Introduction

Judy L. Bolton is a prominent inventor based in Chicago, IL, known for her significant contributions to the field of drug metabolism. With a focus on the screening of xenobiotics and endogenous compounds, her work has implications for drug development and safety.

Latest Patents

Judy L. Bolton holds a patent titled "Screening of xenobiotics and endogenous compounds for metabolic transformation, formation of toxic metabolites, and bioavailability." This innovative method utilizes a high throughput, on-line, pulsed ultrafiltration-mass spectrometric approach to assess whether a compound possesses characteristics suitable for specific applications, such as drug development. The method is instrumental in generating, identifying, and quantifying metabolites formed by drug metabolizing enzymes, including cytochrome P450, UDP-glucuronyltransferases, and glutathione transferases. It allows for rapid screening of drugs to evaluate their metabolism and characterize primary metabolites. Additionally, the method aids in determining bioavailability, absorption, and cell permeability of compounds.

Career Highlights

Judy L. Bolton has made significant strides in her career, particularly through her work at the University of Illinois. Her research has advanced the understanding of drug metabolism and the potential toxicity of metabolites, contributing to safer drug development practices.

Collaborations

Judy has collaborated with Richard B. Van Breemen, enhancing the depth and breadth of her research in the field.

Conclusion

Judy L. Bolton's innovative work in drug metabolism exemplifies the critical role of inventors in advancing medical science. Her contributions continue to influence the development of safer and more effective pharmaceuticals.