Judith M Thorn

Title: Judith M Thorn: Innovator in SH3 Binding Peptides

Introduction

Judith M Thorn is a prominent inventor based in Carrboro, NC (US). She has made significant contributions to the field of biochemistry, particularly in the development of peptides that bind to Src homology region (SH3) domains of proteins. With a total of 4 patents to her name, her work has implications for various biological applications.

Latest Patents

Judith's latest patents include innovative methods for isolating and utilizing Src SH3 binding peptides. These peptides exhibit both general and specific binding affinities for SH3 domains, which are crucial in protein interactions. The invention details the isolation of these peptides from phage-displayed random peptide libraries, specifically targeting bacterial fusion proteins of SH3 domains and glutathione S-transferase (GST). The preferred peptides feature a core 7-mer sequence, flanked by additional amino acid residues, resulting in a total length that optimizes binding affinity. The biochemical activity of these peptides has been demonstrated through both in vitro and in vivo studies.

Career Highlights

Throughout her career, Judith has worked with esteemed institutions, including the University of North Carolina at Chapel Hill. Her research has significantly advanced the understanding of protein interactions and the development of therapeutic peptides.

Collaborations

Judith has collaborated with notable colleagues such as Andrew B Sparks and Brian K Kay, contributing to the advancement of her research and innovations in the field.

Conclusion

Judith M Thorn's work in the development of SH3 binding peptides showcases her innovative spirit and dedication to advancing biochemistry. Her contributions continue to influence the scientific community and pave the way for future discoveries.