Judith E Grisel

Title: Judith E. Grisel: Innovator in Opioid Antagonists

Introduction

Judith E. Grisel is a prominent inventor based in Portland, Oregon. She has made significant contributions to the field of pharmacology, particularly in the development of opioid antagonists. Her work focuses on addressing the physiological effects of opiates, which is crucial in the context of the ongoing opioid crisis.

Latest Patents

Judith E. Grisel holds a patent for "Opioid antagonists and methods of their use." This invention relates to a novel mammalian anti-opioid receptor protein (OFQR) and peptide ligands that bind to OFQR. The patent describes methods of using the OFQ peptide and its analogues to reverse the effects of opiates like morphine. The invention includes the isolation and characterization of the endogenous peptide ligand, which has therapeutic potential in reversing opioid-mediated effects without increasing nociceptive sensitivity.

Career Highlights

Grisel is affiliated with Oregon Health & Science University, where she conducts her research. Her work has been instrumental in advancing the understanding of opioid receptors and their ligands. She has dedicated her career to exploring innovative solutions to combat the challenges posed by opioid addiction and its physiological effects.

Collaborations

Throughout her career, Judith has collaborated with notable researchers, including David K. Grandy and Jeffrey S. Mogil. These collaborations have enriched her research and contributed to the development of effective therapeutic strategies.

Conclusion

Judith E. Grisel's innovative work in the field of opioid antagonists highlights her commitment to addressing critical health issues. Her contributions are paving the way for new therapeutic approaches in the fight against opioid addiction.