This inventor holds 1 USPTO granted patent. Top assignee: Washington University. Active years: 2014.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 2014
Title: Innovations of Joshua Muia
Introduction
Joshua Muia is an accomplished inventor based in St. Louis, MO (US). He has made significant contributions to the field of biochemistry, particularly in the development of fluorogenic substrates for measuring ADAMTS13 activity. His work has implications for understanding various medical conditions related to blood coagulation.
Latest Patents
Joshua Muia holds a patent for a fluorogenic substrate designed for measuring ADAMTS13 activity or ADAMTS13 inhibitor activity. This patent, which is his only one, discloses substrates that can comprise an oligopeptide consisting of up to 80 amino acids from the sequence of von Willebrand Factor (VWF). The oligopeptide may include modifications such as an amino-terminal glycine, a scissile Y-M peptide, and a cysteine substitution. Additionally, the substrate can feature a fluorophore and a fluorescence quencher bound to the oligopeptide on opposite sides of the scissile Y-M peptide. The fluorescence quencher is distinct from the fluorophore, enhancing the substrate's functionality. The oligopeptide can also be encoded by a nucleic acid sequence that may include a His tag, and it can be expressed in a cell or microorganism. Methods for using this fluorogenic substrate to measure ADAMTS13 activity or inhibitor activity are also disclosed.
Career Highlights
Joshua Muia is affiliated with Washington University, where he continues to advance his research in biochemistry and related fields. His innovative work has garnered attention for its potential applications in medical diagnostics and therapeutic development.
Collaborations
Joshua has collaborated with notable colleagues, including Weiqiang Gao and J. Evan Sadler. Their combined expertise contributes to the advancement of research in the field.
Conclusion
Joshua Muia's contributions to the development of fluorogenic substrates represent a significant advancement in the measurement of ADAMTS13 activity. His work at Washington University highlights the importance of innovation in the medical field.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile