Company Filing History:
Years Active: 2004-2009
Title: Innovations by Joshua Gergely
Introduction
Joshua Gergely is an accomplished inventor based in San Francisco, CA. He has made significant contributions to the field of pharmaceutical sciences, particularly in the modulation of the farnesoid X receptor (FXR). With a total of 2 patents, his work focuses on addressing critical health issues related to cholesterol metabolism.
Latest Patents
Gergely's latest patents revolve around FXR modulators. These inventions provide compounds, pharmaceutical compositions, and methods that are useful in modulating FXR. FXR plays a crucial role in controlling the expression level of cholesterol 7α-hydroxylase (cyp7a), which is essential for the oxidative metabolism of cholesterol into bile acids. The compounds he has developed are aimed at treating diseases associated with abnormal cholesterol levels. Specifically, these FXR modulators can block the negative feedback downregulation of cyp7a expression caused by certain cholic acids. Furthermore, as FXR interacts with the retinoid X receptor (RXR), modulation of FXR activity can influence various biological processes, making these compounds valuable in treating obesity, diabetes, lipid-associated disorders, cancer, inflammatory disorders, and other metabolic conditions.
Career Highlights
Throughout his career, Joshua Gergely has worked with notable companies such as Tularik Limited and Amgen Inc. His experience in these organizations has contributed to his expertise in pharmaceutical research and development.
Collaborations
Gergely has collaborated with several professionals in his field, including Jonathan B Houze and Sharon McKendry. These collaborations have likely enhanced his research and innovation efforts.
Conclusion
Joshua Gergely's contributions to the field of pharmaceutical sciences through his patents on FXR modulators highlight his commitment to addressing significant health challenges. His work continues to pave the way for advancements in the treatment of various metabolic disorders.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.