Josh Modell

Title: Innovations in CRISPR Technology by Josh Modell

Introduction

Josh Modell is an innovative inventor based in New York, NY (US). He has made significant contributions to the field of gene editing, particularly through his work on enhancing CRISPR technology. His research focuses on improving the precision and efficiency of CRISPR-based editing methods.

Latest Patents

Josh Modell holds a patent titled "Enhancement of CRISPR gene editing or target destruction by co-expression of heterologous DNA repair protein." This patent provides compositions, methods, and kits aimed at improving CRISPR-based editing of DNA targets by utilizing a CRISPR-associated (Cas) enzyme. The enhancement is achieved by combining the Cas enzyme and a CRISPR targeting RNA with a heterologous DNA repair enzyme, which may include RecBCD, AddAB, or AdnAB. The method also incorporates the use of a DNA repair template to introduce changes into the edited DNA, thereby increasing the effectiveness of the CRISPR system.

Career Highlights

Josh Modell is affiliated with The Rockefeller University, where he conducts his research. His work has positioned him as a key figure in the advancement of CRISPR technology, contributing to the broader understanding of gene editing.

Collaborations

Some of his notable coworkers include Luciano Marraffini and Jon McGinn, who collaborate with him on various research projects related to CRISPR and gene editing technologies.

Conclusion

Josh Modell's innovative work in enhancing CRISPR technology represents a significant advancement in the field of genetic engineering. His contributions are paving the way for more precise and effective gene editing methods, which could have far-reaching implications in medicine and biotechnology.