Joseph Makowiecki

Title: Joseph Makowiecki: Innovator in Virus Purification and Chromatography

Introduction

Joseph Makowiecki is a notable inventor based in Oxford, MA (US), recognized for his contributions to the fields of virus purification and chromatography. With a total of 5 patents to his name, he has made significant advancements that enhance the efficiency and effectiveness of virus purification processes.

Latest Patents

One of his latest patents focuses on a virus purification and formulation process. This innovative method is designed for purifying flaviviruses, including the Yellow Fever Virus, Japanese Encephalitis virus, Dengue virus, and West Nile virus. The process is characterized by its ability to produce a highly purified flavivirus product with a low level of sucrose, minimizing virus loss typically encountered in prior art purification methods. It effectively captures and purifies the virus while separating it from host cell proteins and DNA, ensuring that these contaminants are left behind. Additionally, this process can be utilized to inactivate and concentrate the virus for use in various formulations.

Another significant patent involves the development of single-use slurrying and chromatography systems. This invention introduces methods and systems for chromatography that utilize a flexible container designed to fit within a support structure. The container is equipped with at least one inlet and outlet, along with a separation barrier that divides the container into a resin-containing portion and a drainage portion. This innovative design allows for efficient fluid passage while excluding resin material from the drainage area. The system also features adjustable agitators that can be raised or lowered, enabling the chromatography resin to operate in either a settled, packed-bed configuration or a mixed, slurry configuration.

Career Highlights

Throughout his career, Joseph Makowiecki has worked with prominent companies in the life sciences sector, including GE Healthcare Bio-Sciences Corp. and Global Life Sciences Solutions USA LLC. His work in these organizations has contributed to the advancement of technologies that are crucial for medical and scientific research.

Collaborations

Joseph has collaborated with notable professionals in his field, including Parrish M. Galliher and John J. Vicalvi. These collaborations have further enriched his work and contributed to the development of innovative solutions in virus purification and chromatography.

Conclusion

Joseph Makowiecki's contributions to the fields of virus purification and chromatography demonstrate his commitment to innovation and excellence. His patents reflect a deep understanding of the