Location History:
- Wilmington, DE (US) (1989 - 1991)
- San Diego, CA (US) (1996 - 2008)
Company Filing History:
20 out of 75 
5 out of 16,338 
3 out of 53 
Years Active: 1989-2008
Title: Joseph Edward Semple: Innovator in Pharmaceutical Chemistry
Introduction
Joseph Edward Semple is a distinguished inventor based in San Diego, CA, known for his significant contributions to the field of pharmaceutical chemistry. With an impressive portfolio of 30 patents, Semple has pioneered various innovations, particularly in the modulation of protein tyrosine phosphatases and the development of novel compounds that impact blood vessel formation.
Latest Patents
Among his latest patents, one notable invention is the development of thiazole and thiadiazole inhibitors of tyrosine phosphatases. These compounds are designed to modulate the activity of protein tyrosine phosphatase 1B, a critical enzyme in cellular signaling. Another significant patent involves the creation of aromatic heterocyclic non-covalent inhibitors of urokinase and blood vessel formation. These novel compounds possess a guanidino moiety that makes them valuable for both in vitro monitoring of plasminogen activator levels and in vivo treatments for conditions related to excessive blood vessel formation.
Career Highlights
Throughout his career, Joseph has worked with renowned organizations, such as Corvas International, Inc. and E.I. du Pont de Nemours and Company, where he honed his skills and contributed to innovative projects in drug formulation and development. His expertise in pharmaceutical chemistry has led to advancements that have the potential to significantly impact therapeutic approaches.
Collaborations
Collaborating with notable professionals in the field, such as Terence Kevin Brunck and William Charles Ripka, Joseph has been able to enhance his research and development efforts. These partnerships have not only expanded his knowledge but have also fostered a collaborative environment that encourages innovative thinking in drug development.
Conclusion
Joseph Edward Semple's contributions to pharmaceutical chemistry through his extensive patent portfolio demonstrate his commitment to innovation and problem-solving in medicine. His work continues to be influential, paving the way for future advancements in the treatment of various medical conditions. With each invention, Semple exemplifies the spirit of innovation that drives progress in the scientific community.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.