This inventor holds 2 USPTO granted patents. Top assignee: Chiron Diagnostics Corporation. Active years: 1997-1998.
Company Filing History:
Years Active: 1997-1998
Title: Joseph E Connolly: Innovator in Chemiluminescent Assays
Introduction
Joseph E Connolly is a notable inventor based in Dedham, MA (US), recognized for his contributions to the field of chemiluminescent assays. With a total of 2 patents, Connolly has made significant advancements in the detection and quantification of analytes through innovative methodologies.
Latest Patents
Connolly's latest patents include a Non-separation specific binding chemiluminescent assay. This assay is based on the observation that when acridinium ester labeled tracers bind to their corresponding binding conjugate immobilized on a metal oxide solid phase, the measurable chemiluminescent light emission of the labeled tracer bound to the solid phase is quenched compared to the free fraction tracer that is unattached to the solid phase. The invention provides a non-separation specific binding assay to detect or quantify the presence of an analyte, where the entire reaction mixture is flashed, and the modulated signal is associated with a reference, thus determining the amount or presence of the analyte in the sample. This method avoids the disadvantages inherent in heterogeneous assays that require multiple separations.
Another significant patent is the Mixed luminescent conjugate test. This method allows for the detection or quantification of multiple substances or at least one substance along with an internal reference material in a test sample using at least two different luminescent labeled conjugates. Each conjugate is activated to emit light under different process conditions. The invention also includes test kits containing these conjugates for detecting or quantifying the presence or absence of substances in a test sample.
Career Highlights
Joseph E Connolly is associated with Chiron Diagnostics Corporation, where he has contributed to the development of innovative diagnostic solutions. His work has been instrumental in enhancing the accuracy and efficiency of diagnostic assays.
Collaborations
Connolly has collaborated with notable coworkers, including Michael J Lee and Eve H Barlow, who have contributed to his research and development efforts.
Conclusion
Joseph E Connolly's innovative work in chemiluminescent assays has significantly impacted the field of diagnostics. His patents reflect a commitment to advancing technology that improves the detection and quantification of analytes.