Joseph A Mamone

Title: Joseph A Mamone: Innovator in DNA Polymerase Technology

Introduction

Joseph A Mamone is a notable inventor based in Parma, OH (US). He has made significant contributions to the field of biotechnology, particularly in the development of DNA polymerases. With a total of 2 patents to his name, Mamone's work has advanced the understanding and application of these essential enzymes.

Latest Patents

Mamone's latest patents include innovative technologies that enhance the functionality of DNA polymerases. One of his patents is for a Modified Pol-II type DNA polymerase, which features a unique alteration where an alanine at the nucleotide binding site is replaced with a hydroxy-containing amino acid. This modification aims to improve the enzyme's performance in various applications. Another significant patent is for a thermostable DNA polymerase derived from Thermoanaerobacter. This enzymatically active polymerase exhibits at least 80% homology in its amino acid sequence to a contiguous 40 amino acid sequence of the DNA polymerase from Thermoanaerobacter thermohydrosulfuricus, showcasing its potential for use in high-temperature reactions.

Career Highlights

Joseph A Mamone is currently employed at Amersham Life Science, Inc., where he continues to push the boundaries of DNA polymerase research. His work has not only contributed to the scientific community but has also paved the way for practical applications in molecular biology and genetic engineering.

Collaborations

Mamone collaborates with talented individuals in his field, including coworkers Maria Davis and Dan Sha. Their combined expertise fosters an environment of innovation and creativity, leading to groundbreaking advancements in biotechnology.

Conclusion

Joseph A Mamone's contributions to DNA polymerase technology exemplify the spirit of innovation in the scientific community. His patents reflect a commitment to enhancing the capabilities of these vital enzymes, which are crucial for various biotechnological applications.