Company Filing History:
4 out of 1,325 
3 out of 197 
Years Active: 1994-2005
Title: Joseph A. Madri: Innovator in Genetic Engineering
Introduction
Joseph A. Madri is a notable inventor based in North Branford, CT (US). He has made significant contributions to the field of genetic engineering, particularly in the development of universal donor cells. With a total of 4 patents to his name, Madri's work has the potential to revolutionize therapeutic applications.
Latest Patents
One of Madri's latest patents involves genetically engineered cells that can serve as universal donor cells. These cells are designed for applications such as the reconstruction of vascular linings and the administration of therapeutic agents. The innovative design includes a coding region that provides protection against complement-based lysis, which is crucial in preventing hyperacute rejection. Furthermore, the natural genome of these cells is altered to ensure that functional proteins encoded by class II or both class I and class II major histocompatibility complex genes do not appear on the cell's surface. This modification helps avoid attacks by T-cells. Additionally, these cells can incorporate a self-destruction mechanism, allowing them to be removed from the host when they are no longer needed.
Career Highlights
Throughout his career, Joseph A. Madri has worked with prestigious institutions, including Yale University and the Oklahoma Medical Research Foundation. His research and innovations have garnered attention in the scientific community, contributing to advancements in medical technology.
Collaborations
Madri has collaborated with notable colleagues, including Leonard Bell and Peter J. Sims. These partnerships have further enhanced his research and development efforts in the field of genetic engineering.
Conclusion
Joseph A. Madri's contributions to genetic engineering, particularly through his patents on universal donor cells, highlight his innovative spirit and dedication to advancing medical science. His work continues to inspire future developments in therapeutic applications.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.